منابع مشابه
The role of microRNAs during the genesis of medulloblastomas induced by the hedgehog pathway
Constitutive hedgehog (Hh) signaling is associated with the genesis of medulloblastomas (MB). The objective of this study is to identify special microRNAs (miRNAs) regulated by the Hh pathway, and to clarify the role of miRNAs during the genesis of MB induced by sustained Hh activation. In the primary screening, we used stem-loop RT-PCR to test the expression of 90 different miRNAs in the wildt...
متن کاملSpontaneous hemorrhage in medulloblastomas.
A newborn girl was delivered vaginally by vac uum extraction following fetal cardiac deceleration and a prolonged second stage of labor . The baby had a right-sided cephalohematoma and right facial palsy as well as opisthotonos. Noncontrast CT demonstrated hemorrh age into enlarg ed lateral ventric les and a high-density area in the right cerebellopontine angle sugg esting an intraparenc hymal ...
متن کاملSporadic Medulloblastomas Contain PTCH Mutations1
Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin's syn drome, is an autosomal dominant disorder that predisposes to develop mental defects and various forms of cancer. PTCH was recently proposed as a candidate gene for NBCCS due to its frequent mutation in basal cell carcinomas, the cancer most often associated with this syndrome. Another NBCCS-associated cancer is medulloblastoma, a com...
متن کاملTranslational applications of microRNA genes in medulloblastomas.
PURPOSE To provide a critical assessment of the clinical translational applications of microRNA (miRNA) genes in medulloblastomas. METHODS Data were obtained from MEDLINE using Boolean-formatted keyword queries. Top articles were selected for critical analyses - depending on the novelty of findings, qualitative assessment of the citation index and relevance to the diagnosis, prognosis and the...
متن کاملMedulloblastomas: new directions in risk stratification.
Medulloblastomas (MBs) are the most common malignant brain tumors in children. Current therapeutic approaches combine surgery, radiotherapy, and chemotherapy. Although, there has been significant improvement in long-term survival rates, the tumor remains incurable in about a third of patients while cognitive deficits and other sequelae of therapy are common among long-term survivors. Hence a ma...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2009
ISSN: 0148-396X,1524-4040
DOI: 10.1227/01.neu.0000349643.33882.d2